PrEP Provider Toolkit

Patient Eligibility


Contraindications for Pre-Exposure Prophylaxis

PrEP is not indicated if ANY of the following applies:

  • Is <12 years old
  • Weighs <35 kg (77 lbs)
  • Does not meet the required eCrCl cutoffs1
  • Takes severely contraindicated drugs2
  • Has an indication for HIV post-exposure prophylaxis (PEP)3
  • HIV+ or HIV unknown4
  • High clinical suspicion for acute HIV infection5
  • Injectable CAB (Apretude) cannot be used in those with buttock implants or fillers


  1. F/TDF (Truvada): eCrCl must be ≥ 60ml/min
    F/TAF (Descovy): eCrCl must be ≥ 30ml/min
  2. F/TDF (Truvada): adefovir
    F/TAF (Descovy): St. John’s Wort, rifampin, rifabutin, rifapentine
    CAB (Apretude): rifampicin, rifapentine, carbamazepine, oxcarbazepine, phenytoin, phenobarbital
  3. Substantial risk of HIV acquisition in the past 72 hours
  4. Requires a negative lab-based 4th-gen HIV Ag/Ab test OR POC HIV Ag/Ab test (Abbott Determine).
    If the patient has been on oral PrEP/PEP in the past 3 months or injectable PrEP in the past year, also needs a negative HIV-RNA test in the past week.
    Oral fluid tests or HIV-Ab only POC tests are not recommended.
  5. Substantial HIV-exposure event AND symptoms of ARS unexplained by a more likely diagnosis in the past 4 weeks
Table 2. Contraindications to utilize PrEP