PrEP Provider Toolkit

Patient Eligibility


The CDC published the latest national guideline for PrEP in December 2021. It includes several tables that detail all of the patient indications for PrEP use which can be found here.

The following table summarizes this information with minor modifications to improve simplicity and includes certain details that were omitted.

Indications for Pre-Exposure Prophylaxis

PrEP is indicated if ALL of the following applies:

  • Is ≥12 years old
  • Weighs ≥35kg (77 lbs)
  • Has had a negative HIV test within the last week1
  • And ONE of the following risk factors in the past 6 months

Risk Factors:

  • High-risk sex2 with a partner(s) of unknown HIV status
  • Sex with an HIV+ partner
  • Diagnosed and/or treated for a STI4
  • Share injection drug equipment with partner(s) of unknown HIV status5
  • Requested and/or utilized non-occupational post-exposure prophylaxis (nPEP)
  • Requesting PrEP without disclosing further details

Indications for Specific Therapies:

  • F/TDF (Truvada) - eCrCl ≥ 60ml/min6
  • F/TAF (Descovy) - MSM/TGWSM only, eCrCl ≥ 30ml/min
  • CAB (Apretude) - no eCrCl cutoff


  1. Lab-based 4th-gen HIV Ab/Ag test OR a POC HIV Ag/Ab test (Abbott Determine).
    Oral fluid tests or HIV-Ab only POC tests are not recommended. Additional HIV-RNA testing is recommended if the patient has been on oral PrEP/PEP in the past 3 months or injectable PrEP in the past year.
  2. High risk sex: inconsistent condom use, anal sex, transactional sex, or sex+substance abuse with partner(s) of unknown HIV status.
  3. HIV+ partners with viral loads consistently <200 copies/mL for ≥6 consecutive months pose a negligible risk of sexually transmitting HIV. U=U: (15) undetectable = untransmittable
  4. Chlamydia, gonorrhea, syphilis, genital herpes (16), bacterial vaginosis (17),  trichomoniasis. (18).
  5. U=U has not been proven in HIV transmission that occurs through IV drug use
  6. eCrCl: estimated creatinine clearance. Calculated using the Cockcroft-Gault Equation
Table 1. Indications to utilize PrEP